1 Frescura M, Berry M, Corfield A, Carrington S, Easty D. Evidence of hyaluronan in human tears and secretions of conjunctival cultures. Biochem Soc Trans 1994;22:228S.
2 Lerner L, Schwartz D, Hwang D, Howes E, Stern R. Hyaluronan and CD44 in the human cornea and limbal conjunctiva: letter to the editor. Exp Eye Res 1998;67:481-4.
3 Results from a clinical trial in which a total of 291 subjects were enrolled wearing a range of marketed soft contact lenses and using various soft contact lens care products. Subjects were dispensed Biotrue and participated in a CAWI (Computer Aided Web Interviewing) between day 7 and day 11 of the clinical trial. Subject responses were measured using a six-point Likert Scale in which 1 = strongly disagree and 6 = strongly agree. Results represent reported percentage agreement ratings.
4 Results of in vitro study performed to evaluate the rate of release of sodium hyaluronan (HA) from both traditional hydrogel (Bausch + Lomb SofLens®38 contact lenses, SofLens for Astigmatism lenses, and Vistakon ACUVUE 2) and silicone hydrogel contact lenses (Bausch + Lomb PureVision® contact lenses, Vistakon ACUVUE Oasys, Vistakon ACUVUE Advance, CIBA O 2OPTIX, CIBA Night & Day, and CooperVision Biofinity) over a 20-hour time period. Lenses were placed in Bausch + Lomb standard lenses cases and soaked overnight in Biotrue prepared with HA tagged with fluorescein. Hank’s balanced salt solution (HBSS) was dripped over the lenses at a rate that approximates tear film secretion in the human eye as determined by Reddy I, et al. Ocular Therapeutics and Drug Delivery. Technomic Publishing Co. 1996; 174. The solution that rinsed off the lenses was collected hourly over a 20-hour period and the fluorescence intensity was detected. A standard curve was used to determine the concentration of fluorescein-tagged HA present in each rinse solution. The extended presence of fluorescein-tagged HA in the rinse solutions indicates the percent of HA retained on the lens surface.